Understanding the difference between Ehlers Danlos Syndrome and Hypermobility Syndrome

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Connective tissues play a vital role in providing structure, support, and stability to our bodies. Ehlers-Danlos Syndrome (EDS) and Hypermobility Syndrome are two conditions that primarily affect connective tissues, leading to various symptoms and challenges. In this blog post, we’ll delve into what Ehlers-Danlos Syndrome and Hypermobility Syndrome are, how they differ, and where their similarities lie.

Ehlers-Danlos Syndrome (EDS)

Ehlers-Danlos Syndrome is a group of genetic disorders that affect the body’s ability to produce collagen, a crucial protein that contributes to the strength and elasticity of connective tissues. Collagen is found in the skin, blood vessels, tendons, ligaments, and other organs. As a result of faulty collagen production, individuals with EDS often experience hypermobility (excessive joint flexibility), skin that is more elastic and fragile, and a range of other symptoms. There are several subtypes of EDS, each with distinct features:

  1. Hypermobile EDS (hEDS): This subtype primarily involves joint hypermobility, chronic joint pain, and skin that bruises easily. Other symptoms may include gastrointestinal issues, fatigue, and problems with cardiovascular and autonomic functions.
  2. Classical EDS (cEDS): Individuals with cEDS often have hypermobility, fragile and easily bruised skin, and are prone to scarring. They might also develop joint dislocations, hernias, and other connective tissue-related issues.
  3. Vascular EDS (vEDS): This is the most serious subtype, characterized by a risk of arterial and organ rupture due to weakened blood vessels. People with vEDS have translucent skin and are prone to bruising. This subtype can have life-threatening complications.
  4. Other subtypes: There are several rarer subtypes of EDS, each with distinct characteristics and genetic mutations.

Hypermobility Syndrome

Hypermobility Syndrome, also known as Joint Hypermobility Syndrome (JHS), is a condition characterized by excessive joint flexibility. While EDS and Hypermobility Syndrome share the common feature of joint hypermobility, there are differences in how they are diagnosed and the extent of their symptoms.

Key Differences and Similarities

  1. Genetic Basis: EDS is primarily caused by genetic mutations that affect collagen production. On the other hand, Hypermobility Syndrome is generally not associated with specific genetic mutations and is often considered a clinical diagnosis based on joint flexibility and associated symptoms.
  2. Symptoms: While joint hypermobility is a shared feature, EDS tends to present with a broader range of symptoms, such as fragile skin, easy bruising, and other organ involvement (depending on the subtype). Hypermobility Syndrome usually focuses more on joint-related symptoms.
  3. Skin and Tissue Involvement: EDS is characterized by various skin and tissue abnormalities due to collagen defects. In contrast, Hypermobility Syndrome generally does not involve significant skin fragility or elasticity issues.
  4. Subtypes and Severity: EDS has distinct subtypes with varying levels of severity and potential complications, including life-threatening ones. Hypermobility Syndrome, on the other hand, is often considered less severe, with its primary impact being joint-related symptoms.
  5. Diagnosis: Diagnosing EDS requires evaluating clinical criteria, genetic testing, and sometimes specialized tests like skin biopsies. Diagnosis of Hypermobility Syndrome is based on joint flexibility and the presence of related symptoms.


In summary, both Ehlers-Danlos Syndrome and Hypermobility Syndrome involve joint hypermobility, but they differ in their underlying causes, symptoms, and potential complications. EDS is a group of genetic disorders affecting collagen production, leading to a wider array of symptoms and potential complications, while Hypermobility Syndrome primarily focuses on joint flexibility and associated symptoms. Proper diagnosis and management are essential for individuals with either condition to ensure they receive appropriate care and support for their unique challenges. If you suspect you or someone you know may have either of these conditions, it’s important to consult a medical professional for proper evaluation and guidance.

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